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Morphological and molecular basis of the Central Nervous System and its Pathologies - Syllabus
Anatomical bases and molecular networks in the Central Nervous system and its pathologies - Syllabus

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TIZIANA BREVINI (responsabile dell'insegnamento)

CdL in SCIENZE BIOTECNOLOGICHE VETERINARIE (Classe LM-9) Immatricolati fino all'aa 2015/2016 - Laurea Magistrale - 2016/2017

Insegnamento obbligatorio / Compulsory course
Anno di corso / Year of course1s
Periodo di svolgimentosecondo / second trimestre
Settori scientifico disciplinari / Scientific fields
  • VET/01 - Anatomia degli animali domestici
  • VET/03 - Patologia generale e anatomia patologica veterinaria
Crediti (CFU) obbligatori / ECTS credits (CFU) compulsory8
Crediti (CFU) facoltativi / ECTS credits - facultative-

Informazioni generali / general information

Obiettivi: The course focus on the relationship between applied biotechnology and animal welfare in farm, laboratory and companion animals. Oxidatively generated stress, related causes and the relationship between oxidative status and farming systems are discussed. Biomarkers of oxidative stress applied to the evaluation of animal health status are considered.

Lingua dell'insegnamento / Language of instruction: inglese

Programma di studio / Syllabus

Short description english flag

The course is articulated in two teaching units:
the unit of Morphology and Function of the CNS focuses on Central and Peripheral Nervous System development and organization, including also gene regulation of neurogenesis. Practical sessions will train students on microscope identification of main neural structures and data acquisition and analysis from confocal and MRI images.
The unit of Molecular pathology of the CNS will focus on the main diseases of CNS, including Alzheimer, Parkinson and prion diseases, as well as the defense mechanism. Focus will be on molecular pathology, and on the animal models currently used.

Programma / Syllabus Unit: Molecular pathology of the CNS:

LECTURES
Lecture 1: ageing
Lecture 2: Brain inflammation
Lecture 3: Muscular Dystrophy
Lecture 4: Prion diseases
Lecture 5: Alzheimer disease
Lecture 6: Parkinson disease
Lecture 7: Multiple Sclerosis

PRACTICES
Histopathology of the main brain and Peripheral nervous tissue
Purification and activation of blood monocytes as model for working with brain mononuclear cells


Programma / Syllabus Unit: Molecular pathology of the CNS per non frequentanti / not attendant students

LECTURES
Lecture 1: ageing
Lecture 2: Brain inflammation
Lecture 3: Muscular Dystrophy
Lecture 4: Prion diseases
Lecture 5: Alzheimer disease
Lecture 6: Parkinson disease
Lecture 7: Multiple Sclerosis

PRACTICES
Papers describing in details the histopathological and molecular lesion in the Central and Peripheral nervous system will be uploaded onto ARIEL platform and provided to the students

Bibliografia e altri materiali didattici / Readings Unit: Molecular pathology of the CNS:

Handouts will be available to students through ARIEL platform

Bibliografia e altri materiali didattici / Readings Unit: Molecular pathology of the CNS per non frequentanti / not attendant students

Handouts will be available to students through ARIEL platform

Programma / Syllabus Unit: Morphology and Function of the CNS:

Lectures
CNS organization; Neurons, Ganglia and Nerves (2 hours)
Internal capsule and ventricles; Willis circulatory system (1 hour)
CNS: Brain and cortical areas, pons, midbrain, diencephalon, basal ganglia, cerebellum (3 hours)
Neurotransmitters and neuromodulators of the SNC. Spinal cord (1 hour)
Ascending pathways, somatosensory systems. Descending pathways, motor systems (1 ora)
Development of the brain, spinal cord, and nerves. (1 hour)
Neurogenic areas in the brain (1 hour)
Gene regulation of neurogenesis, differentiation of neural progenitors. (1 hour)
The neurogenic niche. Engrafting and homing of neural progenitorsi. Neuro-phenotype-related experiments using knock –out mice (2 hours)
Sympathetic System (1 hour),
Paraympathetic System (1 hour),
Enteric (1 hour);
Neuroendocrine: Hypotalamus, Pituitary and Pineal glands (2 hours);
Action Potentials and nervous transmission. Myelinization and salutatory transmission (2 hours)
Synapsis. Neuro-muscular junctions; Eccitatoty and inhibitory Neurotransmitters, Reuptake (3 hours)

Practical training
Microscopy session on Neurons, Ganglia and Nerves (2 hours)
Microscopy session on Neural tissue sections (2 hours)
Microscopy session on Spinal cord (C3;T2,L4) (2 hours)
Confocal images of Pituitary and Pineal glands (2 hours)
Microscopy session on Sciatic Nerve (2 hours)
Gap junctions and Synapsis (2 hours)
Data acquisition and analysis from confocal images (2 hours)
Data acquisition and analysis from MRI images (2 hours)

Programma / Syllabus Unit: Morphology and Function of the CNS per non frequentanti / not attendant students

Lectures
CNS organization; Neurons, Ganglia and Nerves (2 hours)
Internal capsule and ventricles; Willis circulatory system (1 hour)
CNS: Brain and cortical areas, pons, midbrain, diencephalon, basal ganglia, cerebellum (3 hours)
Neurotransmitters and neuromodulators of the SNC. Spinal cord (1 hour)
Ascending pathways, somatosensory systems. Descending pathways, motor systems (1 ora)
Development of the brain, spinal cord, and nerves. (1 hour)
Neurogenic areas in the brain (1 hour)
Gene regulation of neurogenesis, differentiation of neural progenitors. (1 hour)
The neurogenic niche. Engrafting and homing of neural progenitorsi. Neuro-phenotype-related experiments using knock –out mice (2 hours)
Sympathetic System (1 hour),
Paraympathetic System (1 hour),
Enteric (1 hour);
Neuroendocrine: Hypotalamus, Pituitary and Pineal glands (2 hours);
Action Potentials and nervous transmission. Myelinization and salutatory transmission (2 hours)
Synapsis. Neuro-muscular junctions; Eccitatoty and inhibitory Neurotransmitters, Reuptake (3 hours)

Practical training
Microscopy session on Neurons, Ganglia and Nerves (2 hours)
Microscopy session on Neural tissue sections (2 hours)
Microscopy session on Spinal cord (C3;T2,L4) (2 hours)
Confocal images of Pituitary and Pineal glands (2 hours)
Microscopy session on Sciatic Nerve (2 hours)
Gap junctions and Synapsis (2 hours)
Data acquisition and analysis from confocal images (2 hours)
Data acquisition and analysis from MRI images (2 hours)

Bibliografia e altri materiali didattici / Readings Unit: Morphology and Function of the CNS:

Handouts

Bibliografia e altri materiali didattici / Readings Unit: Morphology and Function of the CNS per non frequentanti / not attendant students

Handouts

Modalità di esame, prerequisiti, esami propedeutici / Prerequisites, exams and assessment

Esame / Examunico
Modalità di accertamento conoscenze / Type of assessmentEsame
Giudiziovoto verbalizzato in trentesimi

Prerequisiti e modalità di esame written exam

Written exam

Organizzazione didattica / Structure of the course

Unit: Molecular pathology of the CNS

obbligatorio / compulsory

Settori e relativi crediti / Scientific fields

  • VET/01 - Anatomia degli animali domestici
  • VET/03 - Patologia generale e anatomia patologica veterinaria

  • cfu: / ects: 3
Attività didattiche previste / Learning activities

Esercitazioni: 12 ore / hours

Lezioni: 12 ore / hours

Docenti / Teachers

Unit: Morphology and Function of the CNS

obbligatorio / compulsory

Settori e relativi crediti / Scientific fields

  • VET/01 - Anatomia degli animali domestici
  • VET/03 - Patologia generale e anatomia patologica veterinaria

  • cfu: / ects: 5
Attività didattiche previste / Learning activities

Esercitazioni: 12 ore / hours

Lezioni: 24 ore / hours

Ricevimento docenti / Teacher's office hours

Orario di ricevimento Docenti / Teacher's office hours
Docente / TeacherOrario di ricevimento / Office's hoursLuogo di ricevimento / Office location
TIZIANA BREVINI (responsabile dell'insegnamento)tutti i giorni previo appuntamento
FABRIZIO CECILIANIDipartimento di Scienze Veterinarie e Sanità Pubblica - Sezione Patologia Generale e Parassitologia

Altre informazioni / Further information

L’apprendimento degli aspetti relativi al sistema nervoso. L’anatomia, la funzione e la regolazione del Sistema Nervoso Centrale e Periferico sono trattate in dettaglio e allargate allo sviluppo fetale embrionale e fetale dei sistemi stessi. Le Patologie trattate includono la mallattia di Alzheimer, la malattia di Parkinson, le prionosi e la sclerosi multipla, che verranno discusse per quello che riguarda la patogenesi ed i principali modelli animali utilizzati.