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Functional genomics and the molecular basis of differentiation - Syllabus
Functional genomics and the molecular basis of differentiation - Syllabus

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CHIARA BAZZOCCHI (responsabile dell'insegnamento)

CdL in SCIENZE BIOTECNOLOGICHE VETERINARIE (Classe LM-9) immatricolati dal 2016/17 - Laurea Magistrale - GAMETI, CELLULE, TESSUTI:APPLICAZIONI IN RIPRODUZIONE E TERAPIA - 2017/2018

Insegnamento obbligatorio / Compulsory course
Anno di corso / Year of course2s
Periodo di svolgimentoprimo / first trimestre
Settori scientifico disciplinari / Scientific fields
  • AGR/17 - Zootecnica generale e miglioramento genetico
  • VET/06 - Parassitologia e malattie parassitarie degli animali
Crediti (CFU) obbligatori / ECTS credits (CFU) compulsory8
Crediti (CFU) facoltativi / ECTS credits - facultative-

Informazioni generali / general information

Obiettivi: The objective of the course is to provide students with: 1) a general overview on the principal methods for the study of bacterial genomes (genome sequencing techniques, genome annotation, phylogenetic studies); a general overview on the single cell genomic and trancriptomic techniques; 3) information and training in the advances in the understanding of the molecular basis of genomic and epigenetic mechanisms in gene expression in livestock species.

Lingua dell'insegnamento / Language of instruction: Inglese

Programma di studio / Syllabus

Short description english flag

The objective of the course is to provide students with: 1) a general overview on the principal methods for the study of genomes (genome sequencing techniques, genome annotation, phylogenetic studies); a general overview on the single cell genomic and trancriptomic techniques

Programma / Syllabus Unit: Genomics and epigenetics in vertebrates:

Genes, markers and the genome
DNA and RNA , sequencing technologies available today
Epigenetics of Mammalian Gamete and Embryo Development
Epigenetics of Cloned Preimplantation Embryos of Domestic
Roles of Imprinted Genes in Fertility and Promises of the Genome-Wide technologies .
Genomic Imprinting and Imprinted Gene Clusters in the Bovine Genome
Epigenetics and Animal Health
Epigenetics and microRNAs in Animal Health

Programma / Syllabus Unit: Genomics and epigenetics in vertebrates per non frequentanti / not attendant students

Genes, markers and the genome
DNA and RNA , sequencing technologies available today
Epigenetics of Mammalian Gamete and Embryo Development
Epigenetics of Cloned Preimplantation Embryos of Domestic
Roles of Imprinted Genes in Fertility and Promises of the Genome-Wide technologies .
Genomic Imprinting and Imprinted Gene Clusters in the Bovine Genome
Epigenetics and Animal Health
Epigenetics and microRNAs in Animal Health

Bibliografia e altri materiali didattici / Readings Unit: Genomics and epigenetics in vertebrates:

Livestock Epigenetics
Hasan Khatib (Editor)
ISBN: 978-0-470-95859-9
February 2012, Wiley-Blackwell

Bibliografia e altri materiali didattici / Readings Unit: Genomics and epigenetics in vertebrates per non frequentanti / not attendant students

Livestock Epigenetics
Hasan Khatib (Editor)
ISBN: 978-0-470-95859-9
February 2012, Wiley-Blackwell

Programma / Syllabus Unit: Genomics and molecular basis of differentiation in model invertebrate organisms and pathogens:

Single cell genome sequencing: 1) Single cell isolation methods; 2) Cell lysis and gDNA extraction; 3) Whole genome amplification (MDA).
Single cell transcriptomics: methods and applications.
Next generation sequencing techniques.
Application of NGS to the analysis of microbiome and bacterial transcriptome.
Study of bacterial genome evolution by the use of phylogenetic analysis.
Pratic lessons:
Use of LINUX operating system.
Assembly, annotation and phylogenesis of procariotic genomes.
Analysis of metagenomic data obtained after a shutgun approach.

Programma / Syllabus Unit: Genomics and molecular basis of differentiation in model invertebrate organisms and pathogens per non frequentanti / not attendant students

Single cell genome sequencing: 1) Single cell isolation methods; 2) Cell lysis and gDNA extraction; 3) Whole genome amplification (MDA).
Single cell transcriptomics: methods and applications.
Next generation sequencing techniques.
Application of NGS to the analysis of microbiome and bacterial transcriptome.
Study of bacterial genome evolution by the use of phylogenetic analysis.
Pratic lessons:
Use of LINUX operating system.
Assembly, annotation and phylogenesis of procariotic genomes.
Analysis of metagenomic data obtained after a shutgun approach.


Bibliografia e altri materiali didattici / Readings Unit: Genomics and molecular basis of differentiation in model invertebrate organisms and pathogens:

Materiale fornito direttamente dal docente

Bibliografia e altri materiali didattici / Readings Unit: Genomics and molecular basis of differentiation in model invertebrate organisms and pathogens per non frequentanti / not attendant students

Materiale didattico fornito direttamente dal docente

Modalità di esame, prerequisiti, esami propedeutici / Prerequisites, exams and assessment

Esame / Examunico
Modalità di accertamento conoscenze / Type of assessmentEsame
Giudiziovoto verbalizzato in trentesimi

Prerequisiti e modalità di esame Modalità esame: scritto

Modalità esame: scritto

Organizzazione didattica / Structure of the course

Unit: Genomics and epigenetics in vertebrates

obbligatorio / compulsory

Settori e relativi crediti / Scientific fields

  • AGR/17 - Zootecnica generale e miglioramento genetico
  • VET/06 - Parassitologia e malattie parassitarie degli animali

  • cfu: / ects: 4
Attività didattiche previste / Learning activities

Esercitazioni: 12 ore / hours

Lezioni: 18 ore / hours

Docenti / Teachers

Unit: Genomics and molecular basis of differentiation in model invertebrate organisms and pathogens

obbligatorio / compulsory

Settori e relativi crediti / Scientific fields

  • AGR/17 - Zootecnica generale e miglioramento genetico
  • VET/06 - Parassitologia e malattie parassitarie degli animali

  • cfu: / ects: 4
Attività didattiche previste / Learning activities

Esercitazioni: 24 ore / hours

Lezioni: 12 ore / hours

Ricevimento docenti / Teacher's office hours

Orario di ricevimento Docenti / Teacher's office hours
Docente / TeacherOrario di ricevimento / Office's hoursLuogo di ricevimento / Office location
CHIARA BAZZOCCHI (responsabile dell'insegnamento)Mercoledì 11.00-12.00DiMeVet; Patologia Generale e Parassitologia
GIULIETTA MINOZZI