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Ethiopathogenesis of hereditary and parasitic diseases - Syllabus
Ethiopathogenesis of hereditary and parasitic diseases - Syllabus

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MARIA LINA LONGERI (responsabile dell'insegnamento)

CdL in SCIENZE BIOTECNOLOGICHE VETERINARIE (Classe LM-9) immatricolati dal 2016/17 - Laurea Magistrale - 2017/2018

Insegnamento obbligatorio / Compulsory course
Anno di corso / Year of course1s
Periodo di svolgimentosecondo / second trimestre
Settori scientifico disciplinari / Scientific fields
  • AGR/17 - Zootecnica generale e miglioramento genetico
  • VET/06 - Parassitologia e malattie parassitarie degli animali
Crediti (CFU) obbligatori / ECTS credits (CFU) compulsory6
Crediti (CFU) facoltativi / ECTS credits - facultative-

Informazioni generali / general information

Obiettivi: The educational objective of the course is to introduce the students to the comprehension of the analytical genomic tools and to the mechanisms and machineries of inherited and parasitic diseases. Some host-parasite molecular mechanisms of interaction will also been considered. The course will also illustrate the spontaneous and experimental animal models for the understanding of the genetic and pathogenetic basis of parasitic diseases.

Lingua dell'insegnamento / Language of instruction: English

Metodi didattici /Activities: Lectures and practical sessions

Programma di studio / Syllabus

Short description english flag

The integrated course will be divided into 2 education units:
Molecular pathology of parasitic diseases
Genomic analysis of inherited diseases

Programma / Syllabus Unit: Genomic analysis of inherited diseases:

LECTURES:
- Genetic and physical maps of domestic animals.
- Genome Wide Sequencing High-throughput systems, DNA and RNA sequencing
- Whole genome amplification, SNP array and Genome Wide Association Studies for genome mapping of inherited diseases
- Genomic variability and host-parasite interaction: Leishmaniosis and Varroatosis
PRACTICALS:
- On-line practice on Genomic databases.
- Journal clubs on genome sequencing project in domestic animals, genome mapping (Homozigosity mapping, case / control studies, trios) and gene identification in inherited
diseases and in parasitic diseases, the latter limited to those addressed in the lectures.
- Visits to research and service centers equipped with high-throughput platforms.


Programma / Syllabus Unit: Genomic analysis of inherited diseases per non frequentanti / not attendant students

LECTURES:
- Genetic and physical maps of domestic animals.
- Genome Wide Sequencing High-throughput systems, DNA and RNA sequencing
- Whole genome amplification, SNP array and Genome Wide Association Studies for genome mapping of inherited diseases
- Genomic variability and host-parasite interaction: Leishmaniosis and Varroatosis
PRACTICALS:
- On-line practice on Genomic databases.
- Journal clubs on genome sequencing project in domestic animals, genome mapping (Homozigosity mapping, case / control studies, trios) and gene identification in inherited
diseases and in parasitic diseases, the latter limited to those addressed in the lectures.
- Visits to research and service centers equipped with high-throughput platforms.

Bibliografia e altri materiali didattici / Readings Unit: Genomic analysis of inherited diseases:

Course matherials will be uploaded on ARIEL platform

Bibliografia e altri materiali didattici / Readings Unit: Genomic analysis of inherited diseases per non frequentanti / not attendant students

Course matherials will be uploaded on ARIEL platform

Programma / Syllabus Unit: Molecular pathology of parasitic diseases:

LECTURES:
1. Advanced diagnostic techniques for the study of the molecular mechanisms of parasitic diseases (2 hs)
2. Immunopathology of parasitic diseases and parasitic strategies od immune response evasion: leishmaniosis and filariosis (4 hs)
3. Animal models for the understanding of the genetic and pathogenetic basis of parasitic diseases (2 hs)
4. Molecular mechanisms of resistance and sensitivity to animal parasitic diseases: varroatosis, toxoplasmosis and neosporosis (4 hs)

PRACTICALS:
The practical part of the course will teach the student the application of methods described in the lectures and specifically, genetic expression and molecular diagnostic techniques applied to the study of parasitic diseases and related animal models (12 hs)

Programma / Syllabus Unit: Molecular pathology of parasitic diseases per non frequentanti / not attendant students

1. Advanced diagnostic techniques for the study of the molecular mechanisms of parasitic diseases
2. Immunopathology of parasitic diseases and parasitic strategies od immune response evasion: leishmaniosis and filariosis
3. Animal models for the understanding of the genetic and pathogenetic basis of parasitic diseases
4. Molecular mechanisms of resistance and sensitivity to animal parasitic diseases: varroatosis, toxoplasmosis and neosporosis

SUPPLEMENTARY:
The supplementary part of the programme will deal with the application of genetic expression and molecular diagnostic techniques applied to the study of parasitic diseases and related animal models.

Bibliografia e altri materiali didattici / Readings Unit: Molecular pathology of parasitic diseases:

Handouts will be uploaded on ARIEL platform

Bibliografia e altri materiali didattici / Readings Unit: Molecular pathology of parasitic diseases per non frequentanti / not attendant students

Handouts will be uploaded on ARIEL platform

Modalità di esame, prerequisiti, esami propedeutici / Prerequisites, exams and assessment

Esame / Examunico
Modalità di accertamento conoscenze / Type of assessmentEsame
Giudiziovoto verbalizzato in trentesimi

Prerequisiti e modalità di esame Written examination will be open ended text and/or multiple choice questions
Written examination for the two Units together in the same day

Written examination will be open ended text and/or multiple choice questions
Written examination for the two Units together in the same day

Organizzazione didattica / Structure of the course

Unit: Genomic analysis of inherited diseases

obbligatorio / compulsory

Settori e relativi crediti / Scientific fields

  • AGR/17 - Zootecnica generale e miglioramento genetico
  • VET/06 - Parassitologia e malattie parassitarie degli animali

  • cfu: / ects: 3
Attività didattiche previste / Learning activities

Esercitazioni: 12 ore / hours

Lezioni: 12 ore / hours

Unit: Molecular pathology of parasitic diseases

obbligatorio / compulsory

Settori e relativi crediti / Scientific fields

  • AGR/17 - Zootecnica generale e miglioramento genetico
  • VET/06 - Parassitologia e malattie parassitarie degli animali

  • cfu: / ects: 3
Attività didattiche previste / Learning activities

Esercitazioni: 12 ore / hours

Lezioni: 12 ore / hours

Docenti / Teachers

Ricevimento docenti / Teacher's office hours

Orario di ricevimento Docenti / Teacher's office hours
Docente / TeacherOrario di ricevimento / Office's hoursLuogo di ricevimento / Office location
MARIA LINA LONGERI (responsabile dell'insegnamento)
MICHELE MORTARINOMercoledì 11.00-12.00DIMEVET - Patologia Generale e Parassitologia